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Objective To observe the therapeutic effect and safety of the umbilical blood stem cell transplantation on patients with end-stage cirrhosis.Methods We chose 80 patients diagnosed with end-stage cirrhosis.All the re-lated contraindications were excluded .Communicated with all the patients, 50 patients chose the umbilical blood stem cell transplantation and conservative treatment , and 30 patients only chose conservative treatment .The 50 pa-tients were defined as observation group and the left were defined as control group .After transplantation, clinical symptoms and laboratory data were recorded at the 1 month, 6 month, and 12 month.Results ① 12 months after transplantation, clinical symptoms were improved in 38 cases(76%) in the observation group and that in 12 cases (40%) in the control group.② The laboratory data, including ALB, TBiL, ALT, AST, PTA were improved after transplantation in observation group (P <0.05).No significant difference was found in the control group after thera -py.③ After transplantation, the improvement of ALB, A/G, TBiL, PTA in observation group was higher than the control group(P <0.05).Conclusion After transplantation of the umbilical blood stem cell transplantation , the liver function and life quality of patients are significantly improved .This method is better than conservative treat -ment.The method is safe and effective in the treatment of patients with end -stage cirrhosis.
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Objective To analyze the application value of CT in the diagnosis and invasive evaluation gastrointestinal stromal tumors (GIST).Methods The clinical data of 72 GIST cases examined by spiral CT scan and confirmed by surgery or pathology were analyzed retrospectively,evaluated the invasiveness by the tumor site,pattern,strengthen forms,plain and dual-phase enhanced CT scan value.Results GIST most commonly occurred in the stomach.Forteen cases were misdiagnosed in 72 cases of GIST patients,diagnosis of 5 cases was not made clearly.The differences between arterial,venous phase and scan difference in the same parts of different GIST classification were statistically significant (t =4.2,3.5,13.1,15.8,P ＜ 0.05).The GIST in the same part of the different risk classification scan,arterial,venous CT values;difference between the arterial and scan,venous and scan,the difference was not statistically significant (t =34.8,28.5,39.4,32.2,40.1,P ＞ 0.05).Reconstructed image could show the relationship among the tumor and its surrounding tissue and tumor feeding artery,the existence of which 33 cases of portal collateral,18 cases with the presence of arteriovenous fistula and 17 cases with liver metastasis.Conclusions Invasive different GIST dual-phase enhanced CT scans show that arteriovenous tumors are significantly enhanced;post-processing techniques can help clear the blood vessels and GIST relations with neighboring vessels and tissue imaging requires multi-disciplinary preoperative information analysis to make the right location and diagnosis.
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Objective To explore the relationship between the intelligence condition and the content of ?-aminobutyric acid (GABA) in cerebrospinal fluid (CSF) in epileptic patients.Methods We measured the Intelligence Quotient (IQ) of 40 cases of epileptic patients by using the Wechsler Intellectual Scaled, and tested their CSF-GABA contents by using HPLC.At the same time, factors which might have influence on patient’s IQ were analysed.Results In the 40 cases of epileptic patients, there were 14 cases of patients with FIQ≤89, and occupied 35%.The intelligence condition of epileptic patients was positive relation with the contents of CSF-GABA, education background and patterns of seizure,but was negative relation with the patient's age. Among all factors, content of CSF-GABA was very significant relationship with VIQ, PIQ and FIQ (P
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Objective To analyze the clinical determination and mechanism of poststroke dementia.Methods 186 consecutively hospitalized patients who at admission after stroke,completed clinical valuation of neural-functional defect and intelligence assessments,and head CT scan.Their intelligene performances were assessed again after three months .Results Frequency of poststroke dementia was 32 5% .Poststroke dementia was related to age,level of education,residential area,hypertension ,hyperlipidemia,the location and severity of stroke,history of coronary heart disease and diabetes.But it unrelated to sex,smoking,alcohol drinking and type of stroke.Conclusions Dementia is frequently occurred after stroke,and multiple risk factors contribute to its occurrence